| # | Company name | Colorado Employees | Headquarters | Description |
| 1. | King Soopers | 15,928 | Kroger, Cincinnati | Retail food store |
| 2. | Quest Communications | 14,400 | Denver, CO | Telecommunication-broadband data |
| 3. | Centura Health | 12,377 | Englewood | Health care systems |
| 4. | Safeway | 12,000 | Pleasanton, CA | retail-grocery |
| 5. | HealthOne | 9285 | Denver | Health care services |
| 6. | United Airlines | 7700 | Chicago, Il | Airlines |
| 7. | Wells Fargo Bank West N.A. | 6000 | San Francisco | Financial Services |
| 8. | WorldCom | 6000 | Clinton, MA | Telecommunications |
| 9. | Coors Brewing Co. | 5500 | Golden, CO | Brewers |
| 10. | Exempla Healthcare | 5420 | Denver, CO | Health care services |
| 11. | EchoStar Communications | 4500 | Littleton, CO | Telecommunications-cable TB, Satellite systems |
| 12. | Kaiser Permanente | 4141 | Oakland, CA | Health care services |
| 13. | Xcel Energy | 3712 | Minneapolis, MI | Electric utilities |
| 14. | Ball Corp | 3200 | Broomfield, IN | Electric utilities |
| 15. | Great West Life and Annuity Insurance Co. | 3035 | Manitoba, Canada | Multi-line insurance |
| 16. | University of Colorado Hospital | 2985 | Denver, Colorado | Health care services |
| 17. | Avaya | 2905 | Basking Ridge, N.J. | Telecommunications communications processing |
| 18. | CH2M Hill Companies Ltd. | 2725 | Englewood, CO | Engineering and architectural services |
| 19. | The Children's Hospital | 2042 | Denver, Colorado | Health services |
| 20, | Storage Technology Corp | 2300 | Louisville, Colorado | Computer hardware |
| 21. | University of Denver | 2016 | Denver, Colorado | University |
| 22. | Alpine Access | 2000 | Golden, CO | Business services - call center |
| 23. | First Bank Holding Co. of Colorado | 1940 | Lakewood, CO | Banking |
| 24. | U.S. Bank | 1900 | Minneapolis, MN | Banking |
| 25. | Level 3 | 1850 | Broomfield, CO. | Telecommunication - wholesale services |